Drug interactions
Bumetanide + Venlafaxine
Severity: Moderate
Bumetanide and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both bumetanide and venlafaxine can lower serum sodium, the former through renal losses and the latter through SIADH. The combination may increase the risk of hyponatremia, especially in older or volume-depleted patients. Venlafaxine may also raise blood pressure, opposing the antihypertensive effect of the diuretic.
What this interaction means in plain words
Bumetanide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on sodium balance: diuretic sodium loss plus SNRI-associated SIADH.
What to do
Measure serum sodium at baseline and early in therapy, and monitor blood pressure. Lower the diuretic dose or switch the antidepressant if hyponatremia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Bumetanide with Venlafaxine?
MediHelp rates the interaction as moderate. Bumetanide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both bumetanide and venlafaxine can lower serum sodium, the former through renal losses and the latter through SIADH. The combination may increase the risk of hyponatremia, especially in older or volume-depleted patients. Venlafaxine may also raise blood pressure, opposing the antihypertensive effect of the diuretic.
How serious is the interaction between Bumetanide and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum sodium at baseline and early in therapy, and monitor blood pressure. Lower the diuretic dose or switch the antidepressant if hyponatremia occurs.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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