Drug interactions
Bumetanide + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Bumetanide and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and prolong the QTc, and bumetanide causes potassium loss. Together hypokalemia and ECG changes may be worsened, especially with higher than recommended doses.
What this interaction means in plain words
Bumetanide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist intracellular potassium shift and loop diuretic kaliuresis.
What to do
Monitor serum potassium and magnesium, particularly in patients with cardiac disease or at risk for arrhythmia. Replace electrolytes as needed and do not exceed the recommended inhaler dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bumetanide and Vilanterol / fluticasone furoate inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Bumetanide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and prolong the QTc, and bumetanide causes potassium loss. Together hypokalemia and ECG changes may be worsened, especially with higher than recommended doses.
How serious is the interaction between Bumetanide and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly in patients with cardiac disease or at risk for arrhythmia. Replace electrolytes as needed and do not exceed the recommended inhaler dose.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
