Drug interactions
Bupivacaine + Captopril-hydrochlorothiazide
Severity: Minor
Bupivacaine and Captopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Local anesthetic use, particularly neuraxial block, can cause hypotension from sympathetic blockade. Patients on ACE inhibitors and diuretics may have more pronounced hypotension during anesthesia.
What this interaction means in plain words
Bupivacaine and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupivacaine belongs to Central Nervous System; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotension from sympathetic blockade with renin-angiotensin inhibition and volume depletion.
What to do
Monitor blood pressure during neuraxial or regional anesthesia and be ready to treat hypotension with fluids or vasopressors. The anesthesia team should know about ACE inhibitor and diuretic use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Bupivacaine
- Bupivacaine + Bupivacaine implant Major
- Amlodipine-benazepril + Bupivacaine Moderate
- Benazepril + Bupivacaine Moderate
- Bupivacaine + Bupivacaine liposome Moderate
- Bupivacaine + Captopril Moderate
- Bupivacaine + Dofetilide Moderate
Frequently asked questions
Can I take Bupivacaine with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Bupivacaine and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Local anesthetic use, particularly neuraxial block, can cause hypotension from sympathetic blockade. Patients on ACE inhibitors and diuretics may have more pronounced hypotension during anesthesia.
How serious is the interaction between Bupivacaine and Captopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during neuraxial or regional anesthesia and be ready to treat hypotension with fluids or vasopressors. The anesthesia team should know about ACE inhibitor and diuretic use.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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