Drug interactions
Buprenorphine + Crofelemer
Severity: Minor
Buprenorphine and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut in vitro, but it is minimally absorbed, so a clinically meaningful rise in buprenorphine exposure is unlikely. No significant effect is expected in practice.
What this interaction means in plain words
Buprenorphine and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, with little systemic effect because of minimal absorption.
What to do
No dose change is required; be aware of increased opioid effects such as sedation if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Buprenorphine with Crofelemer?
MediHelp rates the interaction as minor. Buprenorphine and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut in vitro, but it is minimally absorbed, so a clinically meaningful rise in buprenorphine exposure is unlikely. No significant effect is expected in practice.
How serious is the interaction between Buprenorphine and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; be aware of increased opioid effects such as sedation if symptoms appear.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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