Drug interactions
Buprenorphine + Dantrolene
Severity: Moderate
Buprenorphine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness and weakness, which can add to the sedation from buprenorphine. Oral dantrolene may impair alertness and respiratory muscle function in susceptible patients.
What this interaction means in plain words
Buprenorphine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle weakness.
What to do
Monitor for oversedation and respiratory compromise, particularly in patients with lung disease. Advise caution with driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Buprenorphine with Dantrolene?
MediHelp rates the interaction as moderate. Buprenorphine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness and weakness, which can add to the sedation from buprenorphine. Oral dantrolene may impair alertness and respiratory muscle function in susceptible patients.
How serious is the interaction between Buprenorphine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory compromise, particularly in patients with lung disease. Advise caution with driving and machinery.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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