Drug interactions
Buprenorphine + Pegvisomant
Severity: Minor
Buprenorphine and Pegvisomant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids have been reported to be associated with reduced pegvisomant effect, possibly leading to higher IGF-1 levels. The relationship is not firmly established.
What this interaction means in plain words
Buprenorphine and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Pegvisomant belongs to Endocrine.
Why it happens
The mechanism is not established.
What to do
Monitor serum IGF-1 if buprenorphine is started or stopped in a patient on pegvisomant. Adjust the pegvisomant dose according to IGF-1 results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Buprenorphine with Pegvisomant?
MediHelp rates the interaction as minor. Buprenorphine and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids have been reported to be associated with reduced pegvisomant effect, possibly leading to higher IGF-1 levels. The relationship is not firmly established.
How serious is the interaction between Buprenorphine and Pegvisomant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-1 if buprenorphine is started or stopped in a patient on pegvisomant. Adjust the pegvisomant dose according to IGF-1 results.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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