Drug interactions
Chlorpropamide + Pegvisomant
Severity: Moderate
Chlorpropamide and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action, which can improve insulin sensitivity and lower glucose in patients with acromegaly. In patients on chlorpropamide this may increase the risk of hypoglycemia.
What this interaction means in plain words
Chlorpropamide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism improves insulin sensitivity, adding to sulfonylurea glucose lowering.
What to do
Monitor blood glucose after starting pegvisomant and reduce the dose of chlorpropamide or other antidiabetic drugs as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
- Gliclazide + Pegvisomant Moderate
Frequently asked questions
Can I take Chlorpropamide with Pegvisomant?
MediHelp rates the interaction as moderate. Chlorpropamide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action, which can improve insulin sensitivity and lower glucose in patients with acromegaly. In patients on chlorpropamide this may increase the risk of hypoglycemia.
How serious is the interaction between Chlorpropamide and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant and reduce the dose of chlorpropamide or other antidiabetic drugs as needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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