Drug interactions
Ertugliflozin-sitagliptin + Pegvisomant
Severity: Moderate
Ertugliflozin-sitagliptin and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action and can improve glucose tolerance in acromegaly. In diabetic patients on glucose-lowering drugs this may reduce glucose levels and lower the antidiabetic requirement, with possible hypoglycemia.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism reduces insulin resistance, adding to the glucose-lowering effect of antidiabetic drugs.
What to do
Monitor blood glucose after starting pegvisomant or changing its dose, and reduce antidiabetic doses if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Gliclazide + Pegvisomant Moderate
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Pegvisomant?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action and can improve glucose tolerance in acromegaly. In diabetic patients on glucose-lowering drugs this may reduce glucose levels and lower the antidiabetic requirement, with possible hypoglycemia.
How serious is the interaction between Ertugliflozin-sitagliptin and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant or changing its dose, and reduce antidiabetic doses if glucose falls.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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