Drug interactions
Codeine + Pegvisomant
Severity: Moderate
Codeine and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids have been reported to raise the dose requirement of pegvisomant in some acromegaly patients, possibly reducing its effect on IGF-1. The mechanism is unclear.
What this interaction means in plain words
Codeine and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Pegvisomant belongs to Endocrine.
Why it happens
Mechanism is not established.
What to do
Monitor serum IGF-1 and adjust the pegvisomant dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
- Gliclazide + Pegvisomant Moderate
Frequently asked questions
Can I take Codeine with Pegvisomant?
MediHelp rates the interaction as moderate. Codeine and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids have been reported to raise the dose requirement of pegvisomant in some acromegaly patients, possibly reducing its effect on IGF-1. The mechanism is unclear.
How serious is the interaction between Codeine and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-1 and adjust the pegvisomant dose if control worsens.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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