Drug interactions
Dapagliflozin-metformin + Pegvisomant
Severity: Moderate
Dapagliflozin-metformin and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant lowers IGF-1 and growth hormone activity, which improves insulin sensitivity in acromegaly. Patients on antidiabetic drugs may have lower glucose levels and, rarely, hypoglycemia, and labeling advises that doses may need reduction.
What this interaction means in plain words
Dapagliflozin-metformin and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Blockade of growth hormone receptors reduces insulin resistance, adding to glucose lowering.
What to do
Monitor blood glucose after starting pegvisomant and reduce antidiabetic doses if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin-metformin and Pegvisomant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
- Gliclazide + Pegvisomant Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Pegvisomant?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant lowers IGF-1 and growth hormone activity, which improves insulin sensitivity in acromegaly. Patients on antidiabetic drugs may have lower glucose levels and, rarely, hypoglycemia, and labeling advises that doses may need reduction.
How serious is the interaction between Dapagliflozin-metformin and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant and reduce antidiabetic doses if glucose falls.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
