Drug interactions
Buprenorphine + Risperidone
Severity: Moderate
Buprenorphine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can prolong the QT interval and buprenorphine may add a small effect. The combination also adds CNS and respiratory depressant effects. The arrhythmia risk is greatest in patients with other risk factors.
What this interaction means in plain words
Buprenorphine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS depression.
What to do
Get a baseline ECG in patients with cardiac risk factors, correct electrolytes, and monitor for sedation and QTc prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Buprenorphine with Risperidone?
MediHelp rates the interaction as moderate. Buprenorphine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can prolong the QT interval and buprenorphine may add a small effect. The combination also adds CNS and respiratory depressant effects. The arrhythmia risk is greatest in patients with other risk factors.
How serious is the interaction between Buprenorphine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Get a baseline ECG in patients with cardiac risk factors, correct electrolytes, and monitor for sedation and QTc prolongation.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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