Drug interactions
Buprenorphine + Rucaparib
Severity: Minor
Buprenorphine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak to moderate CYP3A inhibitor in vitro and clinically, so it may modestly increase buprenorphine concentrations. The likely result is more opioid-related sedation, though the effect is expected to be small.
What this interaction means in plain words
Buprenorphine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, which may reduce buprenorphine metabolism.
What to do
Monitor for increased sedation or respiratory depression after rucaparib is started. Lower the buprenorphine dose only if symptoms of excess opioid effect appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Buprenorphine with Rucaparib?
MediHelp rates the interaction as minor. Buprenorphine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak to moderate CYP3A inhibitor in vitro and clinically, so it may modestly increase buprenorphine concentrations. The likely result is more opioid-related sedation, though the effect is expected to be small.
How serious is the interaction between Buprenorphine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or respiratory depression after rucaparib is started. Lower the buprenorphine dose only if symptoms of excess opioid effect appear.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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