Drug interactions
Buprenorphine + Sevoflurane
Severity: Moderate
Buprenorphine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval and buprenorphine may have a small additive effect. Both also cause additive respiratory and CNS depression during anesthesia.
What this interaction means in plain words
Buprenorphine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS and respiratory depression.
What to do
Monitor ECG and ventilation perioperatively, keep potassium and magnesium normal, and titrate anesthetic and opioid doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Buprenorphine with Sevoflurane?
MediHelp rates the interaction as moderate. Buprenorphine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval and buprenorphine may have a small additive effect. Both also cause additive respiratory and CNS depression during anesthesia.
How serious is the interaction between Buprenorphine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and ventilation perioperatively, keep potassium and magnesium normal, and titrate anesthetic and opioid doses.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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