Drug interactions
Buprenorphine + Trazodone
Severity: Moderate
Buprenorphine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong the QT interval and buprenorphine may add a minor effect. Both also cause sedation, and trazodone has serotonergic activity, so serotonin syndrome is a rare possibility.
What this interaction means in plain words
Buprenorphine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, CNS depression and serotonergic effects.
What to do
Monitor for sedation and serotonin toxicity, and check an ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Buprenorphine with Trazodone?
MediHelp rates the interaction as moderate. Buprenorphine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong the QT interval and buprenorphine may add a minor effect. Both also cause sedation, and trazodone has serotonergic activity, so serotonin syndrome is a rare possibility.
How serious is the interaction between Buprenorphine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and serotonin toxicity, and check an ECG in patients with QT risk factors.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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