Drug interactions
Buprenorphine + Triclabendazole
Severity: Moderate
Buprenorphine and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so combining them may increase the risk of serious ventricular arrhythmia. The risk is higher in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Buprenorphine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Consider ECG monitoring in patients with other QT risk factors, since triclabendazole is given only for a short course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine and Triclabendazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Buprenorphine with Triclabendazole?
MediHelp rates the interaction as moderate. Buprenorphine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, so combining them may increase the risk of serious ventricular arrhythmia. The risk is higher in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Buprenorphine and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Consider ECG monitoring in patients with other QT risk factors, since triclabendazole is given only for a short course.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
