Drug interactions
Chloroquine + Triclabendazole
Severity: Major
Chloroquine and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so used together they may increase the risk of ventricular arrhythmia. Triclabendazole labeling cautions against combining it with QT-prolonging drugs.
What this interaction means in plain words
Chloroquine and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloroquine belongs to Anti Parasitic; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation.
What to do
Avoid the combination where possible, or delay one agent. If unavoidable, obtain an ECG and correct electrolytes before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Chloroquine with Triclabendazole?
MediHelp rates the interaction as major. Chloroquine and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so used together they may increase the risk of ventricular arrhythmia. Triclabendazole labeling cautions against combining it with QT-prolonging drugs.
How serious is the interaction between Chloroquine and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or delay one agent. If unavoidable, obtain an ECG and correct electrolytes before and during treatment.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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