Drug interactions
Clarithromycin + Triclabendazole
Severity: Major
Clarithromycin and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so their combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Clarithromycin and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation; clarithromycin may also inhibit CYP3A4 involved in triclabendazole metabolism.
What to do
Avoid concurrent use and choose a non-QT-prolonging antibiotic. If necessary, obtain a baseline ECG, correct potassium and magnesium and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Clarithromycin with Triclabendazole?
MediHelp rates the interaction as major. Clarithromycin and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so their combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Clarithromycin and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antibiotic. If necessary, obtain a baseline ECG, correct potassium and magnesium and monitor the QTc.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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