Drug interactions
Amiodarone + Triclabendazole
Severity: Major
Amiodarone and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and triclabendazole may also inhibit CYP2C19, which contributes to amiodarone metabolism. Together they may increase the risk of arrhythmia.
What this interaction means in plain words
Amiodarone and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with possible CYP2C19 inhibition raising amiodarone levels.
What to do
Avoid the combination where possible, or obtain a baseline ECG and correct electrolytes. Monitor QTc during the short triclabendazole course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Amiodarone with Triclabendazole?
MediHelp rates the interaction as major. Amiodarone and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and triclabendazole may also inhibit CYP2C19, which contributes to amiodarone metabolism. Together they may increase the risk of arrhythmia.
How serious is the interaction between Amiodarone and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or obtain a baseline ECG and correct electrolytes. Monitor QTc during the short triclabendazole course.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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