Drug interactions
Crizotinib + Triclabendazole
Severity: Major
Crizotinib and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so taking them together may increase the chance of ventricular arrhythmias including torsades de pointes. Triclabendazole is given for a short course, which limits the exposure window.
What this interaction means in plain words
Crizotinib and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation through effects on cardiac repolarization.
What to do
Avoid the combination if an alternative exists; if unavoidable, check ECG and electrolytes at baseline and monitor during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Crizotinib with Triclabendazole?
MediHelp rates the interaction as major. Crizotinib and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, so taking them together may increase the chance of ventricular arrhythmias including torsades de pointes. Triclabendazole is given for a short course, which limits the exposure window.
How serious is the interaction between Crizotinib and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists; if unavoidable, check ECG and electrolytes at baseline and monitor during treatment.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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