Drug interactions
Buprenorphine buccal + Dantrolene
Severity: Moderate
Buprenorphine buccal and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine causes sedation and respiratory depression, and dantrolene adds drowsiness. Co-use may increase CNS depression.
What this interaction means in plain words
Buprenorphine buccal and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor sedation and respiratory rate, and use the lowest effective doses. Counsel about driving and avoiding other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Buprenorphine buccal with Dantrolene?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine causes sedation and respiratory depression, and dantrolene adds drowsiness. Co-use may increase CNS depression.
How serious is the interaction between Buprenorphine buccal and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and use the lowest effective doses. Counsel about driving and avoiding other sedatives.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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