Drug interactions
Buprenorphine buccal + Dolasetron
Severity: Moderate
Buprenorphine buccal and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine, especially at higher buccal doses, can prolong the QT interval, and dolasetron does the same. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Buprenorphine buccal and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Use another antiemetic if feasible. Otherwise obtain an ECG and correct electrolytes in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Dolasetron?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine, especially at higher buccal doses, can prolong the QT interval, and dolasetron does the same. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Buprenorphine buccal and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use another antiemetic if feasible. Otherwise obtain an ECG and correct electrolytes in patients with cardiac risk factors.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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