Drug interactions
Buprenorphine buccal + Fluconazole
Severity: Moderate
Buprenorphine buccal and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or other risk factors. Fluconazole may also raise buprenorphine exposure through CYP3A4 inhibition, adding to opioid effects.
What this interaction means in plain words
Buprenorphine buccal and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, plus fluconazole inhibition of CYP3A4-mediated buprenorphine metabolism.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and for sedation or respiratory depression, or choose an alternative antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Fluconazole?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or other risk factors. Fluconazole may also raise buprenorphine exposure through CYP3A4 inhibition, adding to opioid effects.
How serious is the interaction between Buprenorphine buccal and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and for sedation or respiratory depression, or choose an alternative antifungal.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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