Drug interactions
Buprenorphine buccal + Hydroxychloroquine
Severity: Moderate
Buprenorphine buccal and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and buprenorphine at higher doses carries a labeled QT warning. Together they may increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Buprenorphine buccal and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation via effects on cardiac repolarization.
What to do
Obtain a baseline ECG in patients with QT risk factors and monitor during therapy, correcting electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and buprenorphine at higher doses carries a labeled QT warning. Together they may increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Buprenorphine buccal and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with QT risk factors and monitor during therapy, correcting electrolytes.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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