Drug interactions
Buprenorphine buccal + Modafinil
Severity: Moderate
Buprenorphine buccal and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may induce CYP3A4, which can lower buprenorphine concentrations and reduce analgesic effect or provoke withdrawal. Modafinil's alertness does not reduce the risk of opioid respiratory depression.
What this interaction means in plain words
Buprenorphine buccal and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 induction by modafinil increasing buprenorphine metabolism, plus opposing CNS effects.
What to do
Monitor for loss of analgesia, withdrawal symptoms and respiratory status, and adjust the buprenorphine dose. Reassess the dose when modafinil is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Buprenorphine buccal with Modafinil?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may induce CYP3A4, which can lower buprenorphine concentrations and reduce analgesic effect or provoke withdrawal. Modafinil's alertness does not reduce the risk of opioid respiratory depression.
How serious is the interaction between Buprenorphine buccal and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of analgesia, withdrawal symptoms and respiratory status, and adjust the buprenorphine dose. Reassess the dose when modafinil is stopped.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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