Drug interactions
Buprenorphine buccal + Nevirapine
Severity: Moderate
Buprenorphine buccal and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower buprenorphine levels, potentially causing withdrawal symptoms or loss of analgesic effect. Clinical data suggest the effect is often modest.
What this interaction means in plain words
Buprenorphine buccal and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4-mediated N-dealkylation of buprenorphine.
What to do
Monitor for withdrawal symptoms, cravings or inadequate analgesia and increase the buprenorphine dose if needed. Reassess dose if nevirapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Buprenorphine buccal with Nevirapine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower buprenorphine levels, potentially causing withdrawal symptoms or loss of analgesic effect. Clinical data suggest the effect is often modest.
How serious is the interaction between Buprenorphine buccal and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms, cravings or inadequate analgesia and increase the buprenorphine dose if needed. Reassess dose if nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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