Drug interactions
Buprenorphine buccal + Sevoflurane
Severity: Moderate
Buprenorphine buccal and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval at higher doses and cause sedation and respiratory depression. Sevoflurane adds QT effects and CNS and respiratory depression.
What this interaction means in plain words
Buprenorphine buccal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression, with possible additive QTc prolongation.
What to do
Continue buprenorphine perioperatively where possible and monitor ventilation, sedation and the ECG during anesthesia. Titrate sevoflurane to effect and plan multimodal analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Buprenorphine buccal with Sevoflurane?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval at higher doses and cause sedation and respiratory depression. Sevoflurane adds QT effects and CNS and respiratory depression.
How serious is the interaction between Buprenorphine buccal and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue buprenorphine perioperatively where possible and monitor ventilation, sedation and the ECG during anesthesia. Titrate sevoflurane to effect and plan multimodal analgesia.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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