Drug interactions
Buprenorphine buccal + Trimipramine
Severity: Moderate
Buprenorphine buccal and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buccal buprenorphine can prolong the QT interval, and trimipramine adds to this effect. Both also cause CNS depression, which adds to sedation.
What this interaction means in plain words
Buprenorphine buccal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Obtain a baseline ECG and monitor in patients with other risk factors for QT prolongation. Counsel on sedation and consider dose reduction if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Trimipramine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buccal buprenorphine can prolong the QT interval, and trimipramine adds to this effect. Both also cause CNS depression, which adds to sedation.
How serious is the interaction between Buprenorphine buccal and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor in patients with other risk factors for QT prolongation. Counsel on sedation and consider dose reduction if it occurs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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