Drug interactions
Dofetilide + Trimipramine
Severity: Contraindicated
Dofetilide and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Trimipramine adds further QT prolongation, so the combination is hazardous.
What this interaction means in plain words
Dofetilide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through potassium channel blockade.
What to do
Avoid the combination and use a non-QT-prolonging antidepressant. Dofetilide initiation requires in-hospital ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
- Pimozide + Trimipramine Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Trimipramine?
MediHelp rates the interaction as contraindicated. Dofetilide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Trimipramine adds further QT prolongation, so the combination is hazardous.
How serious is the interaction between Dofetilide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antidepressant. Dofetilide initiation requires in-hospital ECG monitoring.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Ibutilide, Isocarboxazid. The full list is on the Trimipramine page.
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