Drug interactions
Buprenorphine long-acting + Dolasetron
Severity: Moderate
Buprenorphine long-acting and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine gives sustained exposure with a small QT effect, and dolasetron adds to QT prolongation. The risk is greater in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Buprenorphine long-acting and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Prefer an antiemetic with less QT effect. If co-use is necessary, check an ECG and keep potassium and magnesium in range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Dolasetron?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting injectable buprenorphine gives sustained exposure with a small QT effect, and dolasetron adds to QT prolongation. The risk is greater in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Buprenorphine long-acting and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with less QT effect. If co-use is necessary, check an ECG and keep potassium and magnesium in range.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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