Drug interactions
Buprenorphine long-acting + Hydrochlorothiazide-irbesartan
Severity: Minor
Buprenorphine long-acting and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause hypotension or urinary retention, which may reduce diuretic effect and complicate blood pressure management. Opioid-induced orthostatic hypotension may also add to the effect of antihypertensives. The effect with long-acting buprenorphine is modest.
What this interaction means in plain words
Buprenorphine long-acting and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-related ADH release opposing diuresis, plus additive hypotensive effects.
What to do
Monitor blood pressure, fluid status and electrolytes, and counsel on orthostatic symptoms after injection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Buprenorphine long-acting with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and cause hypotension or urinary retention, which may reduce diuretic effect and complicate blood pressure management. Opioid-induced orthostatic hypotension may also add to the effect of antihypertensives. The effect with long-acting buprenorphine is modest.
How serious is the interaction between Buprenorphine long-acting and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and electrolytes, and counsel on orthostatic symptoms after injection.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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