Drug interactions
Buprenorphine long-acting + Nevirapine
Severity: Moderate
Buprenorphine long-acting and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce buprenorphine exposure from the long-acting injection, potentially causing withdrawal or inadequate treatment of opioid use disorder. The fixed-dose depot cannot be tailored easily.
What this interaction means in plain words
Buprenorphine long-acting and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4, accelerating buprenorphine clearance.
What to do
Monitor for withdrawal symptoms and craving. If inadequate, return to a transmucosal formulation that allows dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Buprenorphine long-acting with Nevirapine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce buprenorphine exposure from the long-acting injection, potentially causing withdrawal or inadequate treatment of opioid use disorder. The fixed-dose depot cannot be tailored easily.
How serious is the interaction between Buprenorphine long-acting and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms and craving. If inadequate, return to a transmucosal formulation that allows dose adjustment.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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