Drug interactions
Buprenorphine long-acting + Sevoflurane
Severity: Moderate
Buprenorphine long-acting and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine maintains steady opioid levels that add to sevoflurane's sedative and respiratory depressant effects. Both can also affect QT interval.
What this interaction means in plain words
Buprenorphine long-acting and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression, with possible additive QTc prolongation.
What to do
Titrate sevoflurane to effect with continuous monitoring of respiration, sedation and the ECG. Plan non-opioid analgesia, as exposure cannot be rapidly withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Buprenorphine long-acting with Sevoflurane?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting injectable buprenorphine maintains steady opioid levels that add to sevoflurane's sedative and respiratory depressant effects. Both can also affect QT interval.
How serious is the interaction between Buprenorphine long-acting and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to effect with continuous monitoring of respiration, sedation and the ECG. Plan non-opioid analgesia, as exposure cannot be rapidly withdrawn.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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