Drug interactions
Buprenorphine long-acting + Sotalol
Severity: Moderate
Buprenorphine long-acting and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine may prolong the QT interval and sotalol adds a strong class III effect. Risk of torsades is increased, and the long-acting depot cannot be quickly withdrawn.
What this interaction means in plain words
Buprenorphine long-acting and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor it, and correct potassium and magnesium. Reconsider the combination if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Sotalol?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine may prolong the QT interval and sotalol adds a strong class III effect. Risk of torsades is increased, and the long-acting depot cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine long-acting and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, and correct potassium and magnesium. Reconsider the combination if QTc lengthens significantly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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