Drug interactions
Buprenorphine long-acting + Zonisamide
Severity: Moderate
Buprenorphine long-acting and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can increase drowsiness, impaired psychomotor performance and, less commonly, respiratory depression. The long-acting injection cannot be quickly withdrawn if sedation develops.
What this interaction means in plain words
Buprenorphine long-acting and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from the opioid and the sedating antiseizure drug.
What to do
Monitor for excessive sedation and respiratory depression, particularly when zonisamide is started or increased. Counsel the patient to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Buprenorphine long-acting with Zonisamide?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can increase drowsiness, impaired psychomotor performance and, less commonly, respiratory depression. The long-acting injection cannot be quickly withdrawn if sedation develops.
How serious is the interaction between Buprenorphine long-acting and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, particularly when zonisamide is started or increased. Counsel the patient to avoid driving and alcohol.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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