Drug interactions
Amobarbital + Zonisamide
Severity: Moderate
Amobarbital and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce zonisamide concentrations because zonisamide is partly metabolized by CYP3A4. Lower levels could reduce seizure control in patients taking zonisamide for epilepsy.
What this interaction means in plain words
Amobarbital and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases zonisamide clearance, shortening its half-life.
What to do
Monitor seizure control and consider zonisamide dose increases if response is lost. Reassess the dose if amobarbital is stopped, since levels will rise again.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
- Asenapine + Zonisamide Moderate
Frequently asked questions
Can I take Amobarbital with Zonisamide?
MediHelp rates the interaction as moderate. Amobarbital and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce zonisamide concentrations because zonisamide is partly metabolized by CYP3A4. Lower levels could reduce seizure control in patients taking zonisamide for epilepsy.
How serious is the interaction between Amobarbital and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider zonisamide dose increases if response is lost. Reassess the dose if amobarbital is stopped, since levels will rise again.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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