Drug interactions
Zonisamide + Zuranolone
Severity: Major
Zonisamide and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked somnolence and impaired driving ability. Adding zonisamide, which also causes CNS depression, may worsen sedation, dizziness and psychomotor impairment.
What this interaction means in plain words
Zonisamide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Zonisamide belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Consider reducing the zuranolone dose if excessive sedation occurs. Counsel patients not to drive or operate machinery for at least 12 hours after each zuranolone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zonisamide
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
- Asenapine + Zonisamide Moderate
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Zonisamide with Zuranolone?
MediHelp rates the interaction as major. Zonisamide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes marked somnolence and impaired driving ability. Adding zonisamide, which also causes CNS depression, may worsen sedation, dizziness and psychomotor impairment.
How serious is the interaction between Zonisamide and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if excessive sedation occurs. Counsel patients not to drive or operate machinery for at least 12 hours after each zuranolone dose.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Acetazolamide, Amisulpride, Amobarbital. The full list is on the Zonisamide page.
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