Drug interactions
Buprenorphine subdermal implant + Dolasetron
Severity: Moderate
Buprenorphine subdermal implant and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has a limited QT-prolonging effect, and dolasetron prolongs the QT interval more clearly. The combined risk is of clinical concern mainly in patients with underlying cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Buprenorphine subdermal implant and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Consider an antiemetic with less QT effect. If combined, check an ECG in at-risk patients and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Dolasetron?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine has a limited QT-prolonging effect, and dolasetron prolongs the QT interval more clearly. The combined risk is of clinical concern mainly in patients with underlying cardiac disease or electrolyte disturbance.
How serious is the interaction between Buprenorphine subdermal implant and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antiemetic with less QT effect. If combined, check an ECG in at-risk patients and correct potassium and magnesium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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