Drug interactions
Buprenorphine subdermal implant + Methamphetamine
Severity: Moderate
Buprenorphine subdermal implant and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine labeling warns of serotonin syndrome with serotonergic drugs, and amphetamines have serotonergic properties. The combination may rarely produce agitation, hyperthermia, tremor and autonomic instability. Stimulant use may also mask opioid sedation.
What this interaction means in plain words
Buprenorphine subdermal implant and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from amphetamine-induced monoamine release and opioid modulation of serotonin.
What to do
Monitor for features of serotonin syndrome, particularly after starting or changing doses. If suspected, stop the serotonergic drug and manage supportively, reassessing buprenorphine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine subdermal implant and Methamphetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Methamphetamine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine labeling warns of serotonin syndrome with serotonergic drugs, and amphetamines have serotonergic properties. The combination may rarely produce agitation, hyperthermia, tremor and autonomic instability. Stimulant use may also mask opioid sedation.
How serious is the interaction between Buprenorphine subdermal implant and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin syndrome, particularly after starting or changing doses. If suspected, stop the serotonergic drug and manage supportively, reassessing buprenorphine.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
