Drug interactions
Buprenorphine subdermal implant + Ranolazine
Severity: Minor
Buprenorphine subdermal implant and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them could increase arrhythmia risk. The implant gives low, steady buprenorphine levels, so the added effect is probably small.
What this interaction means in plain words
Buprenorphine subdermal implant and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG in patients with other QT risk factors and keep electrolytes normal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Ranolazine?
MediHelp rates the interaction as minor. Buprenorphine subdermal implant and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents can prolong the QT interval, so combining them could increase arrhythmia risk. The implant gives low, steady buprenorphine levels, so the added effect is probably small.
How serious is the interaction between Buprenorphine subdermal implant and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with other QT risk factors and keep electrolytes normal.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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