Drug interactions
Buprenorphine subdermal implant + Sevoflurane
Severity: Moderate
Buprenorphine subdermal implant and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine adds to the CNS and respiratory depression caused by sevoflurane, and both may affect the QT interval. Exposure from an implant is continuous and cannot be quickly reduced.
What this interaction means in plain words
Buprenorphine subdermal implant and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression, with possible additive QTc prolongation.
What to do
Titrate sevoflurane to effect and monitor respiration, sedation and the ECG. Plan analgesia in advance, as the implant continues to provide steady-state opioid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Buprenorphine subdermal implant with Sevoflurane?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine adds to the CNS and respiratory depression caused by sevoflurane, and both may affect the QT interval. Exposure from an implant is continuous and cannot be quickly reduced.
How serious is the interaction between Buprenorphine subdermal implant and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to effect and monitor respiration, sedation and the ECG. Plan analgesia in advance, as the implant continues to provide steady-state opioid.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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