Drug interactions
Buprenorphine subdermal implant + Trimipramine
Severity: Moderate
Buprenorphine subdermal implant and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has a modest QT-prolonging effect, and trimipramine adds to it. Sedation can also be additive.
What this interaction means in plain words
Buprenorphine subdermal implant and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Consider ECG monitoring in patients with other QT risk factors. Monitor for sedation and review the need for trimipramine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Trimipramine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine has a modest QT-prolonging effect, and trimipramine adds to it. Sedation can also be additive.
How serious is the interaction between Buprenorphine subdermal implant and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG monitoring in patients with other QT risk factors. Monitor for sedation and review the need for trimipramine.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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