Drug interactions
Buprenorphine transdermal + Dolasetron
Severity: Moderate
Buprenorphine transdermal and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine has been associated with dose-related QT prolongation, and dolasetron also lengthens the QT interval. Using both may raise the risk of torsades de pointes.
What this interaction means in plain words
Buprenorphine transdermal and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Choose an alternative antiemetic when possible. If both are needed, obtain a baseline ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Dolasetron?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal buprenorphine has been associated with dose-related QT prolongation, and dolasetron also lengthens the QT interval. Using both may raise the risk of torsades de pointes.
How serious is the interaction between Buprenorphine transdermal and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antiemetic when possible. If both are needed, obtain a baseline ECG and correct electrolyte abnormalities.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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