Drug interactions
Buprenorphine transdermal + Hydroxychloroquine
Severity: Moderate
Buprenorphine transdermal and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and transdermal buprenorphine carries a labeled QT warning at higher patch strengths. Combination use may increase torsades risk in susceptible patients.
What this interaction means in plain words
Buprenorphine transdermal and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation via effects on cardiac repolarization.
What to do
Monitor ECG in patients with QT risk factors, avoid the highest patch strengths if possible, and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and transdermal buprenorphine carries a labeled QT warning at higher patch strengths. Combination use may increase torsades risk in susceptible patients.
How serious is the interaction between Buprenorphine transdermal and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with QT risk factors, avoid the highest patch strengths if possible, and correct potassium and magnesium.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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