Drug interactions
Buprenorphine transdermal + Trazodone
Severity: Moderate
Buprenorphine transdermal and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine can prolong the QT interval, and trazodone has similar potential, so combined use may add to arrhythmia risk. Both drugs also cause CNS depression and trazodone has serotonergic activity, which adds sedative and serotonin syndrome concerns.
What this interaction means in plain words
Buprenorphine transdermal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, along with additive CNS depression and serotonergic effects.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and monitor the QTc. Watch for excess sedation and signs of serotonin toxicity and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Trazodone?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal buprenorphine can prolong the QT interval, and trazodone has similar potential, so combined use may add to arrhythmia risk. Both drugs also cause CNS depression and trazodone has serotonergic activity, which adds sedative and serotonin syndrome concerns.
How serious is the interaction between Buprenorphine transdermal and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and monitor the QTc. Watch for excess sedation and signs of serotonin toxicity and correct electrolyte abnormalities.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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