Drug interactions
Buprenorphine transdermal + Trimipramine
Severity: Moderate
Buprenorphine transdermal and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with other risk factors. Buprenorphine and tricyclics also add to CNS depression and sedation.
What this interaction means in plain words
Buprenorphine transdermal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation, plus additive CNS depressant effects.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Monitor QTc and sedation, and choose an alternative if QTc is prolonged or other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Trimipramine?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with other risk factors. Buprenorphine and tricyclics also add to CNS depression and sedation.
How serious is the interaction between Buprenorphine transdermal and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Monitor QTc and sedation, and choose an alternative if QTc is prolonged or other QT-prolonging drugs are present.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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