Drug interactions
Bupropion + Canagliflozin-metformin
Severity: Minor
Bupropion and Canagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion and its metabolites may inhibit renal transporters involved in metformin elimination, potentially raising metformin concentrations. The clinical effect is usually modest.
What this interaction means in plain words
Bupropion and Canagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Canagliflozin-metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin.
What to do
Monitor glycemic control and renal function. Reduce the metformin dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Canagliflozin-metformin?
MediHelp rates the interaction as minor. Bupropion and Canagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion and its metabolites may inhibit renal transporters involved in metformin elimination, potentially raising metformin concentrations. The clinical effect is usually modest.
How serious is the interaction between Bupropion and Canagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function. Reduce the metformin dose if adverse effects appear.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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