Drug interactions
Bupropion + Cyclosporin
Severity: Moderate
Bupropion and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise bupropion exposure, increasing the risk of dose-related seizures. Both drugs can also lower seizure threshold, since cyclosporine can cause neurotoxicity.
What this interaction means in plain words
Bupropion and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Mechanism not established; possible effect on bupropion metabolism with additive seizure-threshold lowering.
What to do
Keep bupropion at the lowest effective dose and avoid it in patients with other seizure risk factors. Monitor for neurological symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Cyclosporin?
MediHelp rates the interaction as moderate. Bupropion and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise bupropion exposure, increasing the risk of dose-related seizures. Both drugs can also lower seizure threshold, since cyclosporine can cause neurotoxicity.
How serious is the interaction between Bupropion and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep bupropion at the lowest effective dose and avoid it in patients with other seizure risk factors. Monitor for neurological symptoms.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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