Drug interactions
Bupropion + Empagliflozin-metformin
Severity: Moderate
Bupropion and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may raise metformin exposure by reducing its renal elimination. Higher metformin levels can increase gastrointestinal effects and, in susceptible patients, the risk of lactic acidosis.
What this interaction means in plain words
Bupropion and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin by bupropion or its metabolites.
What to do
Monitor glycemic response and tolerability, and check renal function periodically. Reduce the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion and Empagliflozin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Bupropion and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may raise metformin exposure by reducing its renal elimination. Higher metformin levels can increase gastrointestinal effects and, in susceptible patients, the risk of lactic acidosis.
How serious is the interaction between Bupropion and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response and tolerability, and check renal function periodically. Reduce the metformin dose if adverse effects appear.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
