Drug interactions
Bupropion + Fesoterodine
Severity: Minor
Bupropion and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine's active metabolite is partly cleared by CYP2D6, so bupropion may raise exposure and increase anticholinergic effects such as dry mouth, constipation, and urinary retention.
What this interaction means in plain words
Bupropion and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6 by bupropion reduces clearance of the active metabolite 5-hydroxymethyl tolterodine.
What to do
Monitor for anticholinergic effects and reduce the fesoterodine dose if they are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Fesoterodine
Frequently asked questions
Can I take Bupropion with Fesoterodine?
MediHelp rates the interaction as minor. Bupropion and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fesoterodine's active metabolite is partly cleared by CYP2D6, so bupropion may raise exposure and increase anticholinergic effects such as dry mouth, constipation, and urinary retention.
How serious is the interaction between Bupropion and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce the fesoterodine dose if they are troublesome.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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