Drug interactions
Bupropion + Galantamine
Severity: Moderate
Bupropion and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may increase galantamine exposure through CYP2D6 inhibition, increasing cholinergic adverse effects such as nausea, vomiting, and bradycardia.
What this interaction means in plain words
Bupropion and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated galantamine metabolism by bupropion.
What to do
Monitor for nausea, bradycardia, and gastrointestinal effects, and reduce the galantamine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion and Galantamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Bupropion with Galantamine?
MediHelp rates the interaction as moderate. Bupropion and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may increase galantamine exposure through CYP2D6 inhibition, increasing cholinergic adverse effects such as nausea, vomiting, and bradycardia.
How serious is the interaction between Bupropion and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, bradycardia, and gastrointestinal effects, and reduce the galantamine dose if they occur.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
